CD30/TNFRSF8 Fc Chimera Protein, Mouse
SKU: 41839580047

CD30/TNFRSF8 Fc Chimera Protein, Mouse

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Description

CD30/TNFRSF8 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD30; CD30KI 1; CD30L receptor; D1S166EKi 1; TNFRSF8 Accession Q60846 Amino Acid Sequence Phe19 Thr281, with C hIgG Fc Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Mouse
Synonyms CD30; CD30KI-1; CD30L receptor; D1S166EKi-1; TNFRSF8
Accession Q60846
Amino Acid Sequence Phe19-Thr281, with C-hIgG Fc
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oflzoglu E. et al. (2009) Adv. Exp. Med. Biol. 647:174
2. Kennedy, M.K. et al. (2006) Immunology 118:143.
3.Tarkowski, M. (2003) Curr. Opin. Hematol. 10:267.

Background

CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature mouse CD30 consists of a 264 amino acid (aa) extracellular domain (ECD) with three cysteine-rich repeats, a 27 aa transmembrane segment, and a 190 aa cytoplasmic domain. In contrast, human CD30 includes an additional 90 aa in the ECD and contains six cysteine-rich repeats. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is upregulated in Hodgkin’s disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3,and CCL5. An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

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Exchange/Return Notes
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SKU: 41839580047

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4.8 ★★★★★
Based on 1006 reviews
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Product Reviews
M
Verified Purchase
Michael
Houston, US
★★★★★ 4
Almost Perfect
If you’ve ever seen these things, the foldable ones are just as good as the standard ones. I just wish when you folded it up there was a way to lock it into that position. When you unfold it to play, you lock it into place with the orange locking slide so it doesn’t fold up on you. But when you’re done playing and fold it up, there’s no way to lock it into that position, it can keep unfolding if you carry it around with you, plus the orange locking slide keeps sliding up and down. It’s not a huge deal, but they could’ve made it better.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 29, 2026
S
Verified Purchase
SC
Louisville, US
★★★★★ 5
Helpful
I’ve used Chuckit ball launchers, this one is foldable, great for my back pack when camping with my dog
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 27, 2026
C
Verified Purchase
capriceclassic
New York, US
★★★★★ 5
Awesome for hyper dogs
Color: Blue
AWESOME - I have a dog that just won't stop trying to get me to play with him ALL day! I turn this thing on and he goes nuts and tires himself out...without any help from me. The cover got torn off and torn up in minutes but he doesn't care. He just wants this ball. My other dogs, who are older, aren't really interested. But if you have a hyper dog this is the thing for you and them!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 28, 2026
S
Verified Purchase
Shannon
Cuba, US
★★★★★ 5
Great entertainment, charges quickly!
Color: Orange
Super fun entertainment for dog! Toy ball charges quickly and the charge lasts for at least an hour of playtime for the dog. There are 2 modes. one mode Just lights up, which makes it easy for pet to chase it. The second mode not only lights up, but it also wiggles on the ground Randomly and speeds off in a direction on its own, which really makes it interesting for your dog or cat to follow! Once the ball is not touched for about thirty seconds, it goes dormant and it will stay like that As long as it's charged until somebody touches it, and then it starts up randomly lighting up and moving around the floor on its own And making a vibration noise. It's a lot of fun to watch the dog chase and play with, and it certainly keeps them entertained for a while! The laughs and fun entertainment are definitely worth it. The only downside is that my dog chewed off the soft fabric covering in about twenty minutes.And she's not a real big chewer. It looks better with the covering on it, but even without it, the ball works fine and she plays with it every day.So that is not a showstopper. But good to supervise your dog for safety.In case they are a chewer, and they decide to destroy the cover. But the ball works fine without the cover too!
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Reviewed in the United States on March 12, 2026
S
Verified Purchase
Shanna S.
Omaha, US
★★★★★ 4
Looooves her crazy new ball
Color: Orange, Color: Orange
Our 90lb mastiff/boxer mix Indie is very playful, curious and energetic. She needs toys that engage her and keep her busy. This ball does the job! We’ve had it for less than a week. Here’s what I love and what could be better: PROS: • She dog loves it. She whines for it. She gets absurdly excited when I get it out. She’s a bit of an anxious dog, but had zero problems with it inexplicably coming to life. • It lasts a while on a single charge, so it keeps her busy for a good long time. The longest we’ve used it at a stretch is an hour. • It’s pretty durable. She’s a super chewer (destroyed every “non-destructible” toy we’ve purchased for her), but the actual ball is hard plastic. She gnaws on it and it gets scratches, for sure. But she’s not going to chew it to pieces. • On carpet, it’s reasonably quiet. • It comes with a replaceable silicone button. • It’s easy to charge…just pull off the silicone button and the charging port is inside. • The silicone button is flush with the ball’s hard plastic surface, so there’s no way for her to pull the silicone button out and swallow it or get to the charging port. CONS: • Cover is worthless if your dog is a chewer. It goes on like an envelope with a Velcro closure. We took it off immediately. • Without the cover, it’s very noisy on hardwood floors. To us, it’s worth it. (Though, I work from home, so I might feel differently after the holiday vacation.) • She’s an XL dog, so she can fit the whole ball in her mouth easily and accidentally chomp down on the button and turn the ball off. Not a big deal, just something to know if you’ve got a Lab or larger dog. • With extended playtime, the two halves can come unscrewed, especially with a large dog who uses their paws/jaws on it a lot. Thankfully, it makes a loud buzzing noise when this happens, so we know we need to take it from her and screw it back together. Is this a potential danger? With the rechargeable battery inside, I’d say yes. But we also don’t let her play with this toy without supervision. So keep that in mind. Bottom line: It has its drawbacks, but it keeps her entertained and seems like it should last her at least 6 months with supervised play. Which is honestly REALLY good when we’re talking about Indie, Destroyer of Toys. I’d buy it again.
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Reviewed in the United States on December 31, 2024

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