ITPRIPL1 His Tag Protein, Human
SKU: 9417569335

ITPRIPL1 His Tag Protein, Human

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Description

ITPRIPL1 His Tag Protein, HumanProduct Specification Species Human Synonyms Inositol 1,4,5 trisphosphate receptor interacting protein like 1; ITPRIPL1; KIAA1754L; CD3L1 Accession Q6GPH6 Amino Acid Sequence His25 Gly103, with C terminal His Expression System HEK293 Molecular Weight 10. 1 KDa Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Always centrifuge tubes before

Product Specification


Species Human
Synonyms Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIPL1; KIAA1754L; CD3L1
Accession Q6GPH6
Amino Acid Sequence His25-Gly103, with C-terminal His
Expression System HEK293
Molecular Weight

10.1 KDa

Purity

>95% by SDS-PAGE

Endotoxin <1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution
  • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
  • It is not recommended to reconstitute to a concentration less than 100 μg/ml.
  • Dissolve the lyophilized protein in distilled water.
  • Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


Stability & Storage
  • Lyophilized protein should be stored at ≤ -20℃, stable for one year after receipt.
  • Reconstituted protein solution can be stored at 2-8℃ for 2-7 days.
  • Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months.


Background

Cancer immunotherapy has transformed treatment possibilities, but its effectiveness differs significantly among patients, indicating the presence of alternative pathways for immune evasion. Here, we show that ITPRIPL1 functions as an inhibitory ligand of CD3ε, and its expression inhibits T cells in the tumor microenvironment. 1,4,5-triphosphate receptor-interacting protein-like 1 (ITPRIPL1), a natural CD3 ligand, to evade immune surveillance and promote tumor growth. ITPRIPL1, is also a remarkable NSCLC biomarker. Detecting ITPRIPL1 in tumors can contribute to better diagnosis, CD8 positive T cell infiltration revelation, disease progression surveillance, and prognosis prediction.

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Exchange/Return Notes
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SKU: 9417569335

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