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Description
Biotinylated IL-4R alpha/CD124 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms IL4R,CD124,IL4RA,IL 4 R alpha,IL 4Ra Accession P24394 Amino Acid Sequence Met26 His232 with Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 70 95kDa (Reducing) Purity 95% by SDS PAGE&>85% SEC HPLC Conjugation Biotin Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | IL4R,CD124,IL4RA,IL-4 R alpha,IL-4Ra |
| Accession | P24394 |
| Amino Acid Sequence | Met26-His232 with Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 70-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE&>85% SEC-HPLC |
| Conjugation | Biotin |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Sung M, Sim S, Lim A, Moon JS, Jeon J, Heo K, Kwak W, Park MS, Kwak J, Park E, Yoon S. BCL-2 Multi-Strain Probiotics for Immunomodulation In Vitro and In Vivo Alleviation of Atopic Dermatitis. Microorganisms. 2025 Aug 21;13(8):1950. |
Background
The interleukin-4 receptor alpha (IL-4Rα/CD124) is a crucial 140 kDa transmembrane glycoprotein that functions as the primary signaling component for IL-4. It forms two distinct receptor complexes: the type I receptor with the common gamma chain (γc) specific for IL-4, and the type II receptor with IL-13Rα1 that responds to both IL-4 and IL-13. These receptors mediate key immunological processes including Th2 cell differentiation, alternative macrophage activation, B-cell class switching, and allergic inflammation. The receptor's structure features an extracellular cytokine-binding domain, a transmembrane segment, and a cytoplasmic region containing Box 1 and ITIM signaling motifs. Soluble forms of IL-4Rα generated through alternative splicing or proteolysis can inhibit IL-4 activity by competing for ligand binding. Given its central role in type 2 immunity, IL-4Rα has emerged as an important therapeutic target for allergic diseases such as asthma and atopic dermatitis, with targeted biologics demonstrating clinical efficacy by blocking both IL-4 and IL-13 signaling pathways.
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