Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 8 - Jul 13
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
KGF/FGF-7 Protein, HumanProduct Specification Species Human Synonyms Fibroblast growth factor 7, FGF 7, Heparin binding growth factor 7 (HBGF 7), Keratinocyte growth factor Accession P21781 Amino Acid Sequence Cys32 Thr194 Expression System E. coli Molecular Weight 20 22 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1
Product Specification
| Species | Human |
| Synonyms | Fibroblast growth factor 7, FGF-7, Heparin-binding growth factor 7 (HBGF-7), Keratinocyte growth factor |
| Accession | P21781 |
| Amino Acid Sequence | Cys32-Thr194 |
| Expression System | E.coli |
| Molecular Weight | 20-22 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Am J Transplant. 2021 Sep;21(9):2950-2963. |
Background
Human fibroblast growth factor 7 (FGF-7) is also known as keratinocyte growth factor (KGF). It is a secreted, heparin-binding glycoprotein of 194 amino acids that belongs to the FGF family. FGF-7 is produced exclusively by mesenchymal cells and acts in a paracrine manner on epithelial cells expressing the splice variant FGFR2-IIIb. Upon ligand binding, the receptor dimerizes and initiates downstream signaling through the MAPK/ERK, PI3K/AKT and PLCγ pathways, leading to proliferation, migration, differentiation and survival of epithelial cells. Expression of FGF-7 is strongly up-regulated after skin, lung, kidney or gastrointestinal injury by inflammatory cytokines such as IL-1 and TNF-α, making it a key mediator of wound healing and tissue repair.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy