Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Phospho-MLKL (Ser345) Recombinant Rabbit mAb (S-2439-64)Product Specification Host Rabbit Antigen Phospho MLKL (Ser345) Synonyms Mixed lineage kinase domain like protein; Mlkl Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession Q9D2Y4Q8NB16 Clone Number S 2439 64 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%
Product Specification
| Host | Rabbit |
| Antigen | Phospho-MLKL (Ser345) |
| Synonyms | Mixed lineage kinase domain-like protein; Mlkl |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q9D2Y4、Q8NB16 |
| Clone Number | S-2439-64 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu, Ms |
Background
Phospho-MLKL (Ser345) is the activated, phosphorylated form of the pseudokinase mixed-lineage kinase domain-like protein (MLKL) at serine-345, a critical post-translational modification catalyzed by the necroptotic kinase RIPK3 that triggers MLKL’s oligomerization, translocation to plasma membrane phosphoinositides, and subsequent membrane disruption, thereby executing the terminal, pro-inflammatory cell death pathway known as necroptosis; detection of phospho-MLKL(Ser345) by phospho-specific antibodies thus serves as a specific biomarker for ongoing necroptotic signaling in experimental models and human pathologies including ischemia–reperfusion injury, inflammatory diseases, and certain cancers.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy