Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Alexa Fluor® 488 Mouse Anti-Human IL-22 Antibody (S-3255)Product Specification Host Mouse Antigen IL 22 Synonyms Interleukin 22; Cytokine Zcyto18; IL 10 related T cell derived inducible factor (IL TIF); ILTIF; ZCYTO18; IL22 Location Secreted Accession Q9GZX6 Clone Number S 3255 Antibody Type Mouse mAb Isotype IgG2a,k Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0.
Product Specification
| Host | Mouse |
| Antigen | IL-22 |
| Synonyms | Interleukin-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor (IL-TIF); ILTIF; ZCYTO18; IL22 |
| Location | Secreted |
| Accession | Q9GZX6 |
| Clone Number | S-3255 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
Interleukin-22 (IL-22) is a 20 kDa α-helical cytokine of the IL-10 family that is produced chiefly by activated innate lymphoid cells, Th17, Th22 and γδ T cells, signals exclusively through a heterodimeric receptor complex of IL-22R1 and IL-10R2 to activate STAT3 and, to a lesser extent, STAT1 and STAT5, and functions as a frontline defender of barrier organs by up-regulating antimicrobial peptides (e.g., β-defensins, RegIIIγ), mucins and tight-junction proteins, stimulating epithelial proliferation and survival, while simultaneously suppressing inflammatory cytokine release from tissue-resident immune cells, thereby orchestrating tissue repair, containment of commensal microbes and protection against extracellular bacterial and fungal pathogens; however, its dysregulation contributes to psoriasis, inflammatory bowel disease, fibrosis and certain cancers, making it a key target for therapeutic modulation.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy