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Description
IL-1 RII/CD121b Fc Chimera Protein, HumanProduct Specification Species Human Synonyms beta; CD121b antigen; IL 1 R beta; IL 1 RII; IL1R2; IL1RBCD121 antigen like family member B; IL 1R beta; IL1RII; IL 1RII; IL 1RT2; IL 1RT 2; interleukin 1 receptor, type II; Interleukin 1 receptor beta; MGC47725 Accession P27930 Amino Acid Sequence Phe14 Glu343 with Human IgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | beta; CD121b antigen; IL-1 R beta; IL-1 RII; IL1R2; IL1RBCD121 antigen-like family member B; IL-1R- beta; IL1RII; IL-1RII; IL-1RT2; IL-1RT-2; interleukin 1 receptor, type II; Interleukin-1 receptor beta; MGC47725 |
| Accession | P27930 |
| Amino Acid Sequence | Phe14-Glu343 with Human IgG1 Fc at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Greenfeder, S. et al. (1995) J. Biol. Chem. 270:13757. |
Background
Interleukin-1 receptor type 2 (IL1R2), also referred to as CD121 antigen-like family member B (CDw121b) or the IL-1 type II receptor, is a member of the interleukin-1 receptor family. Two specific IL-1 binding receptors have been identified: IL1RI (also known as IL1RA) and IL1RII (also known as IL1RB).
IL1R2 is a non-signaling receptor that binds to IL1A, IL1B, and IL1RN, and it plays a role in reducing the activities of IL1B. It functions as a decoy receptor by competitively binding to IL1B, thereby preventing its interaction with IL1R1. After binding to IL1B, IL1R2 modulates cellular responses through a non-signaling association with IL1RAP.
Both membrane-bound and secreted forms of IL1R2 show a preference for binding to IL1B, with less affinity for IL1A and IL1RN. The secreted form of IL1R2 has a high affinity for secreted IL1RAP, and the formation of this complex is likely a primary mechanism for the neutralization of IL1B by soluble receptors. It is hypothesized that the type II receptor, in both its membrane-bound and soluble forms, acts as a decoy for IL-1, inhibiting its action by blocking the binding of IL-1 to the signaling type I receptor complex. The recombinant IL-1 soluble receptor type II is a potent antagonist of IL-1 activity.
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