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Description
Alexa Fluor® 647 Rat Anti-Mouse CD184 Antibody (S-R670)Product Specification Host Rat Antigen Mouse CD184 Synonyms C X C chemokine receptor type 4; CXC R4; CXCR 4; Fusin; Leukocyte derived seven transmembrane domain receptor (LESTR); Pre B cell derived chemokine receptor (PB CKR); Stromal cell derived factor 1 receptor (SDF 1 receptor); Cxcr4; Cmkar4; Lestr; Sdf1r Location Lysosome, Endosome, Cell membrane, Cell junction Accession P70658 Clone Number S R670 Antibody Type Rat mAb Isotype IgG2b,k
Product Specification
| Host | Rat |
| Antigen | Mouse CD184 |
| Synonyms | C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; Leukocyte-derived seven transmembrane domain receptor (LESTR); Pre-B-cell-derived chemokine receptor (PB-CKR); Stromal cell-derived factor 1 receptor (SDF-1 receptor); Cxcr4; Cmkar4; Lestr; Sdf1r |
| Location | Lysosome, Endosome, Cell membrane, Cell junction |
| Accession | P70658 |
| Clone Number | S-R670 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD184, also known as CXCR4, is a CXC chemokine receptor encoded by the CXCR4 gene. It is a G protein-coupled receptor that specifically binds to stromal-derived factor-1 (SDF-1, also known as CXCL12), which is important for lymphocyte chemotaxis, hematopoietic stem cell homing, and quiescence. CXCR4 is also a co-receptor for HIV infection in CD4+ T cells, particularly for T-cell tropic HIV strains. Additionally, CXCR4 is involved in neuronal guidance during embryogenesis and adult life, and its dysregulation has been implicated in various diseases, including cancer and epilepsy.
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Exchange/Return Notes
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