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Description
Alexa Fluor® 647 Rat Anti-Mouse CD117 Antibody (S-R681)Product Specification Host Rat Antigen Mouse CD117 Synonyms Mast stem cell growth factor receptor Kit; SCFR; Proto oncogene c Kit; Tyrosine protein kinase Kit; Kit; Sl Location Cell membrane Accession P05532 Clone Number S R681 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rat |
| Antigen | Mouse CD117 |
| Synonyms | Mast/stem cell growth factor receptor Kit; SCFR; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; Kit; Sl |
| Location | Cell membrane |
| Accession | P05532 |
| Clone Number | S-R681 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD117, also known as c-Kit, is a receptor tyrosine kinase involved in cell growth, survival, and differentiation. It is expressed on various cell types, including hematopoietic stem cells, mast cells, melanocytes, and interstitial cells of Cajal in the gastrointestinal tract. CD117 plays a critical role in normal development and immune function, and its dysregulation is associated with several diseases, including cancers such as gastrointestinal stromal tumors (GIST) and acute myeloid leukemia (AML). Additionally, CD117 is a marker for cancer stem cells in some solid tumors and is targeted in cancer therapies.
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