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Description
NCAM-1/CD56 His Tag Protein, RatProduct Specification Species Rat Synonyms N CAM 1, NCAM 1, CD56, MSK39, NCAM1 Accession P13596 1 Amino Acid Sequence Leu20 Thr721, with C terminal His Expression System HEK293 Molecular Weight 95 115kDa (Reducing) Purity 95% by SDS PAGE & >95% by SEC HPLC Endotoxin <0. 1EU g Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Rat |
| Synonyms | N-CAM-1, NCAM-1, CD56, MSK39, NCAM1 |
| Accession | P13596-1 |
| Amino Acid Sequence | Leu20-Thr721, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 95-115kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Reyes AA. et al., 1991, Mol Cell Biol. 11 (3): 1654-61. |
Background
NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobulin superfamily. Human NCAM-1 is synthesized as a 761 aa preproprecursor, containing a signal sequence, a large GPI-linked extracellular domain (ECD), and a short C-terminal prosegment. The mature ECD contains five C-2 type Ig-like domains and two fibronectin type III domains. The mature human ECD shares 93% and 95% aa sequence identity with the mouse and rat NCAM-1 ECD, respectively. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. NCAM1 is involved in neuron-neuron adhesion, neurite fasciculation, the outgrowth of neurites, etc. It has also been shown to be involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Diseases associated with NCAM1 include Rabies and Bile Duct Cancer. Among its related pathways are Neuroscience and RET signaling.
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