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Description
Fas/TNFRSF6/CD95 Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms FAS, ALPS1A, APO1, APT1, CD95, FAS1, FASTM, TNFRSF6, FasR Accession Q9TSN4 Amino Acid Sequence Gln26 Arg171, with C hIgG Fc Expression System HEK293 Molecular Weight 50 60kDa (Reducing) Purity 95% by SDS PAGE & >95% by RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Cynomolgus |
| Synonyms | FAS, ALPS1A, APO1, APT1, CD95, FAS1, FASTM, TNFRSF6, FasR |
| Accession | Q9TSN4 |
| Amino Acid Sequence | Gln26-Arg171, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 50-60kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & >95% by RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30. |
Background
Fas, also known as APO-1 or CD95, belongs to the death receptor subfamily of the TNF receptor superfamily and is a prototypical death receptor characterized by the presence of an 80-amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant.
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