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Description
Alexa Fluor® 488 Rat Anti-Mouse CD169 Antibody (S-R594)Product Specification Host Rat Antigen CD169 Synonyms Sialoadhesin; Sheep erythrocyte receptor (SER); Sialic acid binding Ig like lectin 1 (Siglec 1); Sa; Sn; Siglec1 Location Secreted, Cell membrane Accession Q62230 Clone Number S R594 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | CD169 |
| Synonyms | Sialoadhesin; Sheep erythrocyte receptor (SER); Sialic acid-binding Ig-like lectin 1 (Siglec-1); Sa; Sn; Siglec1 |
| Location | Secreted, Cell membrane |
| Accession | Q62230 |
| Clone Number | S-R594 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD169, also known as Siglec-1 or sialoadhesin, is a type I transmembrane glycoprotein of the immunoglobulin superfamily expressed predominantly on subsets of tissue-resident macrophages and some dendritic cells; it contains 17 extracellular Ig-like domains that together project ~33 nm from the plasma membrane to enable high-avidity binding to α2,3-linked sialic acid moieties on glycoproteins and glycolipids of host cells or pathogens, thereby facilitating pathogen capture, antigen presentation, and adaptive immune priming while simultaneously serving as an entry portal for viruses such as HIV-1, PRRSV, and SARS-CoV-2, and its interferon-inducible expression correlates with both protective immunity and disease severity in infections, cancer, and chronic inflammatory disorders.
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