USP14 His Tag Protein, Human
SKU: 74748852520

USP14 His Tag Protein, Human

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Description

USP14 His Tag Protein, HumanProduct Specification Species Human Synonyms Ubiquitin carboxyl terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin specific processing protease Accession P54578 Amino Acid Sequence Pro2 Gln494

Product Specification


Species Human
Synonyms Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease
Accession P54578
Amino Acid Sequence

Pro2-Gln494 PLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQGGGSHHHHHHHH

Expression System Baculovirus-InsectCells
Molecular Weight 58kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Liquid
Storage Buffer 20mM Hepes, 100mM NaCl, 10%Glycerol, 3mMDTT pH8.0
Stability & Storage

·12 months from date of receipt, -20 to -70 °C as supplied.
·1 month, 2 to 8 °C under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Reference

Front Pharmacol. 2022 Jan 5:12:801328. J Cell Physiol. 2021 May;236(5):3396-3405. Epub 2020 Nov 1.

Background

Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation. USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome. Increasing evidence have shown that USP14 is involved in several canonical signaling pathways, correlating with cancer, neurodegenerative diseases, autophagy, immune responses, and viral infections. The activity of USP14 is tightly regulated to ensure its function in various cellular processes. Due to its intriguing roles in the stabilization of disease-causing proteins and oncology targets, USP14 has garnered widespread interest as a therapeutic target.

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Exchange/Return Notes
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SKU: 74748852520

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4.3 ★★★★★
Based on 567 reviews
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Product Reviews
M
Verified Purchase
Michelle Kim
Houston, US
★★★★★ 4
Everything a Teething Puppy Could Need — Well-Thought-Out Kit
Size: X-Small, Color: Teething Bone
The Nylabone New Puppy Starter Kit is a solid all-in-one solution for the first few months of puppy ownership. It comes with multiple chew toys and bones designed specifically for teething puppies, and my little one took to them right away. The variety keeps him engaged, and I appreciate that each item is designed to be gentle on developing teeth while still satisfying his urge to chew. What differentiates this kit from other puppy chew sets on Amazon is the thoughtful selection of textures and shapes. It’s clear these toys are designed to stimulate gums, promote healthy chewing habits, and even support dental care. I also like that everything is non-toxic and durable enough to survive a few enthusiastic chews. The only reason I didn’t give 5 stars is that the kit might be a bit small for larger breeds, or for puppies that are particularly aggressive chewers. But for standard small to medium pups, it’s a fantastic starter kit that keeps both puppy and owner happy. ✅ Bottom line: A reliable, well-designed starter kit for teething puppies which is thoughtful, durable, and engaging. Makes a great gift for new puppy owners or a practical addition to your own puppy’s toy collection.
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Reviewed in the United States on September 26, 2025
V
Verified Purchase
Valarie Amundsen
Battle Creek, US
★★★★★ 5
Chew
Size: X-Small, Color: Ring Bone
My dog loves this little chewy bone and it’s good for her teeth. That was very cheap on a sale. It’s worth giving it a try highly recommend it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 11, 2026
P
Verified Purchase
princeton von d
Cuba, US
★★★★★ 3
Chicken Flavor Good, But 🔄 Rotation-Resistant✖; Best for Simpler Chewers
Size: X-Small, Color: Ring Bone, Size: X-Small, Color: Ring Bone
🐾 Hi, I’m PVD; plush sophisticate, chew critic, and active curator of rotational toy relevance. This ring bone and I never fully bonded. I sampled it maybe five times in my entire puppyhood before quietly returning it to the bin (with a single judgmental glance). Still, it does have value for the right pup. ⭐ Why I originally wanted to love it: ✔️ XS size works well for very young puppies ✔️ Chicken flavor lasts impressively long ✔️ Freezing offers temporary gum relief ✔️ Durable and safe; no odd odors or shredding 🌀 Why it’s now a respectful 3-star chew in my rotation: ✘ Never became a go-to toy (5 uses max in my life) ✘ Ring shape felt awkward, not natural or chic; hard to grip and maneuver ✘ Texture too tame vs. nubs or detailed chew surfaces ✘ When I was smaller, I much preferred the Nylabone Baby Blue Bone Chew Toy with nubs (my personal classic), and have since matured into nightly Nylabone “Nubz” edible bones This Ring Bone is Best For: • Very young puppies with minimal chew preferences • Dogs who like simple textures and circular shapes • Those just starting enrichment chew play • Freezer treat rotations (briefly) 🚫 Not ideal for: picky pups, advanced chewers, or dogs who analyze toy ergonomics (like myself). 📝 Final Re-Barks: A strong, well-made chew, but lacked the intrigue to make my permanent rotation. Works for basic chew enjoyment; not for pups with elevated taste or toy ambition. — PVD (Chew Strategist, Textural Analyst & Aspire-to-Vine Reviewer 🐶💼)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 17, 2025
K
Verified Purchase
Kaitlynne Lynch
West Palm Beach, US
★★★★★ 5
Puppy loves it!
Size: X-Large, Color: Teething Bone, Size: X-Large, Color: Teething Bone
My small puppy loves this bone! I originally purchased this for a larger dog, but my small 10 pound puppy loves it more. It’s good quality and a softer material for puppies!
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Reviewed in the United States on May 10, 2026
J
Verified Purchase
Jesse Arner
Belleville, US
★★★★★ 4
A hit, but could be stronger
Size: Medium, Color: Ring Bone, Size: Medium, Color: Ring Bone
Gave this to my 11 week old pittie, and she did significant damage within 15 mins. She left a pile of chewed bits on the couch but thankfully didn't eat them. Definitely don't leave unsupervised. That said, she LOVED it and it seemed to help her teething gums so, I'm still giving it a 4/5 Puppy pics for tax
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Reviewed in the United States on June 3, 2026

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