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Description
IGFBP-4 Protein, HumanProduct Specification Species Human Synonyms Insulin like growth factor binding protein 4, IBP 4, IGF binding protein 4, IGFBP 4 Accession P22692 Amino Acid Sequence Asp22 Glu258 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 35 38 kDa (Reducing) Purity >95% by SDS PAGE & HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, 1mM EDTA, pH7. 4 Reconstitution
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4 |
| Accession | P22692 |
| Amino Acid Sequence | Asp22-Glu258 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 35-38 kDa (Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, 1mM EDTA, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | J Clin Invest. 2008 Jul;118(7):2609-19. |
Background
Insulin-like Growth Factor Binding Protein-4 (IGFBP-4) is the smallest member of the IGFBP family, with a molecular weight of approximately 24 kDa, encoded by the IGFBP4 gene located on human chromosome 17q12-21.1. The protein consists of 237 amino acids and contains the conserved N-terminal, C-terminal, and variable L-domains characteristic of the IGFBP family, including two additional interconnected cysteine residues in the L-domain. IGFBP-4 binds both IGF-I and IGF-II with high affinity, exhibiting 2–10 fold higher affinity for IGF-II than for IGF-I. This binding prolongs IGF half-life and inhibits ligand-receptor interactions, thereby attenuating IGF-mediated proliferation and differentiation in most physiological contexts.
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